منابع مشابه
PLK1 Inhibitors: Setting the Mitotic Death Trap
Polo-like kinase 1 (Plk1) regulates mitotic progression in all eukaryotes and has been implicated in the transformation of human cells. Analysis of the cytological and anti-tumor activities of BI 2536, a novel, selective pharmacological inhibitor of Plk1, has connected chemistry and biology to the bedside.
متن کاملMitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.
Taxanes are powerful chemotherapy agents that target the microtubule cytoskeleton, leading to mitotic arrest and cell death; however, their clinical efficacy has been hampered due to the development of drug resistance. Therefore, other proteins involved in spindle assembly are being examined as potential targets for anticancer therapy. The mitotic kinesin, Eg5 is critical for proper spindle ass...
متن کاملThe Effect of Mitotic Inhibitors on Myogenesis in Vitro
The effect of colchicine and other antimitotic drugs was studied in cultures of 11-day chick embryo breast muscle. Exposure of such cultures to 10(-6)M colchicine results in fragmentation of the elongate myotubes into rounded, cytoplasmic sacs (myosacs) containing various numbers of nuclei. Comparison of the dose-response relation between myotube fragmentation and metaphase arrest suggests that...
متن کاملInhibitors of Mitotic Kinesins for Cancer Treatment: Consequences for Neurons
Cancer is among the greatest and most expensive medical challenges in the world, and potentially escalating in prevalence as more carcinogens are introduced into the environment. Not surprisingly, there are ongoing efforts to develop novel therapies, as effective treatments would positively impact the landscape for society. Cancer involves abnormal cells that rapidly proliferate, move, and inva...
متن کاملMathematical Modelling of the Effects of Mitotic Inhibitors on Avascular Tumour Growth
In this paper we build on the mathematical model of Ward and King (1998) to study the effects of high molecular mass mitotic inhibitors released at cell death. The model assumes a continuum of living cells which, depending on the concentration of a generic nutrient, generate movement (described by a velocity field) due to the changes in volumes caused by cell birth and death. The necrotic mater...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2011
ISSN: 1556-0864
DOI: 10.1097/01.jto.0000407560.61287.3f